GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs881375 | 1 | rs6478486 | chr9:123655329 | LOC253039 | chr9:123605320-123616644:+ | -0.36 | -6.09 | 2.72E-9 | Rheumatoid arthritis |
| BLCA | cis | rs7849270 | 1 | rs6478867 | chr9:131903923 | CRAT | chr9:131857075-131873070:- | -0.31 | -5.4 | 1.16E-7 | Blood metabolite ratios |
| BLCA | cis | rs12220238 | 1 | rs6480723 | chr10:75966366 | ADK | chr10:75910965-76469059:+ | 0.3 | 4.62 | 5.23E-6 | Soluble interleukin-2 receptor subunit alpha |
| BLCA | cis | rs4237643 | 1 | rs6485438 | chr11:43686618 | HSD17B12 | chr11:43702143-43878160:+ | -0.44 | -7.37 | 1.05E-12 | Forced vital capacity |
| BLCA | cis | rs4237643 | 1 | rs6485443 | chr11:43696316 | HSD17B12 | chr11:43702143-43878160:+ | 0.43 | 7.28 | 1.9E-12 | Forced vital capacity |
| BLCA | cis | rs11051970 | 1 | rs6488051 | chr12:32532733 | FGD4 | chr12:32638906-32798982:+ | -0.33 | -5.36 | 1.47E-7 | Response to tocilizumab in rheumatoid arthritis |
| BLCA | cis | rs638893 | 1 | rs649338 | chr11:118705654 | NLRX1 | chr11:119039437-119054723:+ | -0.37 | -3.91 | 0.000108 | Vitiligo |
| BLCA | cis | rs2404602 | 1 | rs6495206 | chr15:76870963 | SCAPER | chr15:76640529-77197744:- | -0.2 | -4.47 | 1.03E-5 | Blood metabolite levels |
| BLCA | cis | rs9914544 | 1 | rs6502677 | chr17:18803658 | FAM18B | chr17:18684582-18710026:+ | -0.22 | -4.06 | 6.05E-5 | Educational attainment (years of education) |
| BLCA | cis | rs8078723 | 1 | rs6503530 | chr17:38161823 | ZPBP2 | chr17:38024455-38034144:+ | -0.21 | -3.95 | 9.31E-5 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| BLCA | cis | rs9303401 | 1 | rs6503877 | chr17:56841948 | RAD51C | chr17:56769963-56811690:+ | 0.29 | 5.15 | 4.09E-7 | Cognitive test performance |
| BLCA | cis | rs9303401 | 1 | rs6503882 | chr17:56915761 | RAD51C | chr17:56769963-56811690:+ | 0.28 | 4.9 | 1.43E-6 | Cognitive test performance |
| BLCA | cis | rs6504663 | 1 | rs6504661 | chr17:48580126 | MYCBPAP | chr17:48585745-48608861:+ | 0.27 | 3.87 | 0.000126 | Visceral fat |
| BLCA | cis | rs9902453 | 1 | rs6505152 | chr17:28331466 | EFCAB5 | chr17:28256874-28435469:+ | -0.23 | -4 | 7.57E-5 | Coffee consumption (cups per day) |
| BLCA | cis | rs9902453 | 1 | rs6505158 | chr17:28403348 | EFCAB5 | chr17:28256874-28435469:+ | -0.23 | -3.97 | 8.64E-5 | Coffee consumption (cups per day) |